The Initiation of DNA Replication in Eukaryotes Daniel L. Kaplan
Publisher: Springer International Publishing

Emerging mechanisms of eukaryotic DNA replication initiation. The accurate and timely duplication of the genome is a major task for eukaryotic cells. Cyclin-dependent kinases (CDKs) regulate the progression of the cell cycle in eukaryotes. Eukaryotic DNA replication: from pre- replication complex to initiation complex. Takisawa H(1), Mimura S, Kubota Y. INITIATION OF DNA REPLICATION IN EUKARYOTIC CELLS. Regulation of eukaryotic DNA replication at the initiation step. DNA replication is semi-conservative, one strand serves as the template for the the RNA primers that are synthesized at the initiation sites by these enzymes. Dpb11/Cut5/TopBP1 is evolutionarily conserved and is essential for the initiation of DNA replication in eukaryotes. Mechanism of chromosomal DNA replication initiation and replication fork stabilization in eukaryotes. The Initiation of DNA Replication in Eukaryotes. Initiation of DNA replication in eukaryotic cells. We report that a plasmid replicating in Xenopus egg extracts becomes negatively supercoiled during replication initiation. Eukaryotic Chromosome DNA Replication: Where, When, and How? The initiation of DNA replication is mediated by DnaA, a protein that binds to a region of the origin DNA replication (comparing Prokaryotic to Eukaryotic). Supercoiling requires the initiation. The eukaryotic replisome complex coordinates DNA replication. DNA replication in eukaryotes occurs in three stages: initiation, elongation, and termination, which are aided by several enzymes.